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Issue 26, 2017
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An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

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Abstract

An NIR-emitting probe (λem ∼ 700 nm) with a large Stokes shift (Δλ ≈ 234 nm) is synthesized by using excited-state intramolecular proton transfer (ESIPT). The phenolic proton, which controls ESIPT, acts as a switch to give strong fluorescence at pH ≈ 5. The probe can selectively show lysosome organelles, therefore leading to a lysosome probe without exhibiting “an alkalinizing effect”.

Graphical abstract: An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

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Publication details

The article was received on 24 Jan 2017, accepted on 02 Mar 2017 and first published on 15 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00700K
Citation: Chem. Commun., 2017,53, 3697-3700
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    An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

    D. Dahal, L. McDonald, X. Bi, C. Abeywickrama, F. Gombedza, M. Konopka, S. Paruchuri and Y. Pang, Chem. Commun., 2017, 53, 3697
    DOI: 10.1039/C7CC00700K

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