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Issue 24, 2017
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Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free conditions: an approach to spiro[4.5]cyclohexadienones

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Abstract

A tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement reaction (VCPR) of vinylogous para-quinone methides at low temperature under metal-free conditions has been disclosed for the first time. This method provides an efficient strategy for the construction of a range of spiro[4.5]cyclohexadienones in good yield, exhibiting good functional group tolerance as well as gram-scale capacity.

Graphical abstract: Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free conditions: an approach to spiro[4.5]cyclohexadienones

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Publication details

The article was received on 24 Jan 2017, accepted on 21 Feb 2017 and first published on 21 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00677B
Citation: Chem. Commun., 2017,53, 3485-3488
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    Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free conditions: an approach to spiro[4.5]cyclohexadienones

    Z. Yuan, K. Gai, Y. Wu, J. Wu, A. Lin and H. Yao, Chem. Commun., 2017, 53, 3485
    DOI: 10.1039/C7CC00677B

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