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Issue 25, 2017
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Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance

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Abstract

We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure–activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.

Graphical abstract: Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance

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Publication details

The article was received on 23 Jan 2017, accepted on 22 Feb 2017, published on 22 Feb 2017 and first published online on 22 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00613F
Citation: Chem. Commun., 2017,53, 3512-3515
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    Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance

    F. Ji, C. Wang, H. Wang, G. Liu, B. Chen, L. Hu, G. Jiang, M. Song and Y. Liang, Chem. Commun., 2017, 53, 3512
    DOI: 10.1039/C7CC00613F

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