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Issue 27, 2017
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Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

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Abstract

Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without Aβ oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of Aβ peptides.

Graphical abstract: Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

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Publication details

The article was received on 19 Jan 2017, accepted on 13 Mar 2017 and first published on 13 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00506G
Citation: Chem. Commun., 2017,53, 3886-3889
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    Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

    G. Wen, W. Qin, D. Chen, Y. Wang, X. Yue, Z. Liu, Y. Cao, J. Du, B. Zhou and X. Bu, Chem. Commun., 2017, 53, 3886
    DOI: 10.1039/C7CC00506G

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