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Total Synthesis of Nannocystin Ax


Total synthesis of nannocystin Ax, a natural depsipeptide isolated from myxobacteria recently, has been accomplished concisely. By following a convergent strategy, the target molecule was assembled from three fragments. Each fragment can be synthesized expeditiously from readily achievable compounds. The key elements in this total synthesis features Kobayashi’s remote asymmetric induction with vinylketene silyl N, O-acetal, Roush’s asymmetric crotylboration of aldehyde, Mitsunobu’s esterification and macrocyclization via Stille cross-coupling.

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Publication details

The article was received on 18 Jan 2017, accepted on 20 Apr 2017 and first published on 20 Apr 2017

Article type: Communication
DOI: 10.1039/C7CC00469A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Total Synthesis of Nannocystin Ax

    Y. Zhang, R. Liu and B. Liu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC00469A

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