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Issue 40, 2017
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Total synthesis of nannocystin Ax

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A concise total synthesis of nannocystin Ax, a natural depsipeptide recently isolated from myxobacteria, has been accomplished. By following a convergent strategy, the target molecule was assembled from three fragments. Each fragment can be synthesized expeditiously from readily achievable compounds. The key elements in this total synthesis feature Kobayashi's remote asymmetric induction with vinylketene silyl N,O-acetal, Roush's asymmetric crotylboration of aldehyde, Mitsunobu's esterification and macrocyclization via Stille cross-coupling.

Graphical abstract: Total synthesis of nannocystin Ax

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The article was received on 18 Jan 2017, accepted on 20 Apr 2017 and first published on 20 Apr 2017

Article type: Communication
DOI: 10.1039/C7CC00469A
Citation: Chem. Commun., 2017,53, 5549-5552
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    Total synthesis of nannocystin Ax

    Y. Zhang, R. Liu and B. Liu, Chem. Commun., 2017, 53, 5549
    DOI: 10.1039/C7CC00469A

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