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Issue 32, 2017
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A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

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Abstract

Herein, we report a rapid in vitro assay of amyloid β anti-aggregation reagents using gold nanoparticles as nucleation cores and optical reporters. Based on the colorimetric responses observed with the naked eye, effective anti-aggregation reagents were rapidly (<15 min) distinguished. For these reagents, conventional methods showed fewer amyloid β aggregates and an increased viability of neuroblastoma cells after treatment. We envision that our proposed method will facilitate the discovery of efficient drug components for the treatment of Alzheimer's disease.

Graphical abstract: A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

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Publication details

The article was received on 14 Jan 2017, accepted on 16 Mar 2017 and first published on 16 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00358G
Citation: Chem. Commun., 2017,53, 4449-4452
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    A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

    H. Y. Kim, D. Lee, K. Ryu and I. Choi, Chem. Commun., 2017, 53, 4449
    DOI: 10.1039/C7CC00358G

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