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Issue 29, 2017
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Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

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Abstract

We design and synthesize EpCAM antibodies with Fc-domain site-specific linkers that allow preferential alignment when coated on microfluidic devices for capturing circulating tumor cells (CTCs) from colorectal cancer patients. The aligned coating is shown to increase the capture efficiency of CTCs and microemboli by 1.6 and 3.0-fold, respectively (both P < 0.05).

Graphical abstract: Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

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Publication details

The article was received on 12 Jan 2017, accepted on 15 Mar 2017 and first published on 17 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00247E
Citation: Chem. Commun., 2017,53, 4152-4155
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    Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

    C. Lai, S. Choon Lim, L. Wu, C. Wang, W. Tsai, H. Wu and Y. Chang, Chem. Commun., 2017, 53, 4152
    DOI: 10.1039/C7CC00247E

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