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O 2 -(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

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Abstract

The new nitric oxide (NO) donor O2-(6-oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolate 3c could simultaneously liberate NO as well as an active 3-glutathionyl-2-exomethylene-cyclohexanone 2 in the presence of GSH/GSTπ; exhibit potent antiproliferative activity; repress migration, invasion, and lateral migration of metastatic B16–BL6 cells; and significantly decrease hetero-adhesion of B16–BL6 cells to human umbilical vein endothelial cells.

Graphical abstract: O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

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Publication details

The article was received on 10 Jan 2017, accepted on 07 Apr 2017 and first published on 12 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC00213K
Citation: Chem. Commun., 2017, Advance Article
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    O 2 -(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

    C. Bai, R. Xue, J. Wu, T. Lv, X. Luo, Y. Huang, Y. Gong, H. Zhang, Y. Zhang and Z. Huang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC00213K

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