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Issue 36, 2017
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O 2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

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Abstract

The new nitric oxide (NO) donor O2-(6-oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolate 3c could simultaneously liberate NO as well as an active 3-glutathionyl-2-exomethylene-cyclohexanone 2 in the presence of GSH/GSTπ; exhibit potent antiproliferative activity; repress migration, invasion, and lateral migration of metastatic B16–BL6 cells; and significantly decrease hetero-adhesion of B16–BL6 cells to human umbilical vein endothelial cells.

Graphical abstract: O 2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

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Publication details

The article was received on 10 Jan 2017, accepted on 07 Apr 2017 and first published on 12 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC00213K
Citation: Chem. Commun., 2017,53, 5059-5062
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    O 2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

    C. Bai, R. Xue, J. Wu, T. Lv, X. Luo, Y. Huang, Y. Gong, H. Zhang, Y. Zhang and Z. Huang, Chem. Commun., 2017, 53, 5059
    DOI: 10.1039/C7CC00213K

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