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Issue 28, 2017
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Pore modulation of zirconium–organic frameworks for high-efficiency detection of trace proteins

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Abstract

Tunable electrochemical biosensors based on analogous Zr-MOFs were developed for protein detection, the performances of which rely on the pore sizes and surroundings of the MOFs that show diverse binding behaviors to aptamers and then the targeted proteins. The optimized Zr-MOF-based sensor has high selectivity to lysozyme in a wide concentration range and a low detection limit of 3.6 pg mL−1, with good repeatability, stability, and applicability in real samples. This work will establish a new platform for biosensing and extend the application scope of MOF materials.

Graphical abstract: Pore modulation of zirconium–organic frameworks for high-efficiency detection of trace proteins

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Publication details

The article was received on 03 Jan 2017, accepted on 03 Mar 2017 and first published on 06 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00029D
Citation: Chem. Commun., 2017,53, 3941-3944
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    Pore modulation of zirconium–organic frameworks for high-efficiency detection of trace proteins

    C. Liu, Z. Zhang, M. Chen, H. Zhao, F. Duan, D. Chen, M. Wang, S. Zhang and M. Du, Chem. Commun., 2017, 53, 3941
    DOI: 10.1039/C7CC00029D

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