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Issue 28, 2017
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A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives

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Abstract

A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot sequential catalytic and stoichiometric process, which generates a series of benzobicyclo[4.3.0] compounds containing one quaternary center with up to 94% yield and 20 : 1 dr value. In this reaction, MBH carbonates act as 1,2,3-C3 synthons.

Graphical abstract: A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives

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Publication details

The article was received on 22 Dec 2016, accepted on 16 Mar 2017 and first published on 16 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC10155K
Citation: Chem. Commun., 2017,53, 3974-3977
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    A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives

    Q. Zhang, Y. Zhu, H. Jin and Y. Huang, Chem. Commun., 2017, 53, 3974
    DOI: 10.1039/C6CC10155K

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