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Issue 33, 2017
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The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

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Abstract

We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

Graphical abstract: The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

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Publication details

The article was received on 13 Dec 2016, accepted on 10 Mar 2017 and first published on 10 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC09900A
Citation: Chem. Commun., 2017,53, 4565-4568
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    The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

    L. Sánchez-García, N. Serna, M. Mattanovich, P. Cazzanelli, A. Sánchez-Chardi, O. Conchillo-Solé, F. Cortés, X. Daura, U. Unzueta, R. Mangues, A. Villaverde and E. Vázquez, Chem. Commun., 2017, 53, 4565
    DOI: 10.1039/C6CC09900A

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