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Issue 15, 2017
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Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

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Abstract

An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf2, an efficient Au-catalyzed cyclization–alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates.

Graphical abstract: Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

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Publication details

The article was received on 09 Dec 2016, accepted on 03 Jan 2017 and first published on 03 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09794D
Citation: Chem. Commun., 2017,53, 2315-2318
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    Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

    C. A. Smith, S. E. Motika, L. Wojtas and X. Shi, Chem. Commun., 2017, 53, 2315
    DOI: 10.1039/C6CC09794D

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