Transcriptional regulatory proteins as biosensing tools

Kendrick Turner; Smita Joel; Jessika Feliciano; Agatha Feltus; Patrizia Pasini; Daniel Wynn; Peter Dau; Emre Dikici; Sapna K. Deo; Sylvia Daunert

doi:10.1039/C6CC09512G

Transcriptional regulatory proteins as biosensing tools†

Kendrick Turner,^a Smita Joel,^b Jessika Feliciano,^a Agatha Feltus,^a Patrizia Pasini,^b Daniel Wynn,^b Peter Dau,^b Emre Dikici,^b Sapna K. Deo

^b and Sylvia Daunert

*^b

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* Corresponding authors

^a Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA

^b Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
E-mail: sdaunert@med.miami.edu

Abstract

We have developed sensing systems employing different classes of transcriptional regulatory proteins genetically and chemically modified to incorporate a fluorescent reporter molecule for detection of arsenic, hydroxylated polychlorinated biphenyls (OH-PCBs), and cyclic AMP (cAMP). These are the first examples of optical sensing systems based on transcriptional regulatory proteins.

Chemical Communications

Transcriptional regulatory proteins as biosensing tools†

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