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Issue 34, 2017
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Molecular imaging probes for multi-spectral optoacoustic tomography

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Abstract

Multi-Spectral Optoacoustic Tomography (MSOT) merges the power of high-resolution imaging at tissue depths of several millimeters to centimeters with the advantages of optical imaging, in large part by exploiting spectral detection of endogenous molecules in tissue or exogenous photoabsorbing probes. Current advances in fast-tuning laser technology, image reconstruction and spectral detection schemes have yielded real-time optoacoustic (photoacoustic) imaging spanning applications from microscopy to human imaging. This progress has generated an unprecedented need for imaging probes and reporter gene approaches optimized for optoacoustic signal generation. New classes of probes are emerging and create new opportunities for visualizing morphological and pathophysiological features in vivo, in a non-invasive manner. Here we review recent progress in optoacoustic probes and discuss applications and challenges for biological imaging as well as prospects for clinical translation.

Graphical abstract: Molecular imaging probes for multi-spectral optoacoustic tomography

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Publication details

The article was received on 25 Nov 2016, accepted on 30 Mar 2017 and first published on 30 Mar 2017


Article type: Feature Article
DOI: 10.1039/C6CC09421J
Citation: Chem. Commun., 2017,53, 4653-4672
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    Molecular imaging probes for multi-spectral optoacoustic tomography

    V. Gujrati, A. Mishra and V. Ntziachristos, Chem. Commun., 2017, 53, 4653
    DOI: 10.1039/C6CC09421J

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