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Issue 6, 2017
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Zwitterionic BODIPYs with large stokes shift: small molecular biomarkers for live cells

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Abstract

The two first examples of zwitterionic BODIPYs have been synthesized via a simple SN-Ar methodology. The molecules exhibit excellent optical behavior, such as a large Stokes shift in solution and therefore a very intense emission, and can thus avoid self-quenching. The zwitterionic nature of the molecules was unambiguously elucidated using single crystal XRD studies. The electronic conjugation was investigated by NMR, DFT (NICS (0)) and XRD analysis. Due to their inherent ionic nature, their enhanced solubility in aqueous conditions was exploited for their utility in bio-imaging and cell viability studies. These molecules demonstrate promising localization inside live yeast cells.

Graphical abstract: Zwitterionic BODIPYs with large stokes shift: small molecular biomarkers for live cells

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Publication details

The article was received on 22 Nov 2016, accepted on 14 Dec 2016 and first published on 15 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC09325F
Citation: Chem. Commun., 2017,53, 1096-1099
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    Zwitterionic BODIPYs with large stokes shift: small molecular biomarkers for live cells

    A. R. Sekhar, S. K. Sariki, R. V. R. Reddy, A. Bisai, P. K. Sahu, R. S. Tomar and J. Sankar, Chem. Commun., 2017, 53, 1096
    DOI: 10.1039/C6CC09325F

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