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Issue 26, 2017
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A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

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Abstract

A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H2O2 in living cell lines.

Graphical abstract: A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

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Publication details

The article was received on 25 Nov 2016, accepted on 27 Feb 2017 and first published on 01 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC09127J
Citation: Chem. Commun., 2017,53, 3701-3704
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    A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

    S. I. Reja, M. Gupta, N. Gupta, V. Bhalla, P. Ohri, G. Kaur and M. Kumar, Chem. Commun., 2017, 53, 3701
    DOI: 10.1039/C6CC09127J

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