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Issue 25, 2017
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Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme

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Abstract

Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h−1).

Graphical abstract: Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme

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Publication details

The article was received on 08 Nov 2016, accepted on 08 Mar 2017 and first published on 09 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC08873B
Citation: Chem. Commun., 2017,53, 3579-3582
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    Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme

    S. Lopez, L. Rondot, C. Cavazza, M. Iannello, E. Boeri-Erba, N. Burzlaff, F. Strinitz, A. Jorge-Robin, C. Marchi-Delapierre and S. Ménage, Chem. Commun., 2017, 53, 3579
    DOI: 10.1039/C6CC08873B

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