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Issue 31, 2017
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From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

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Abstract

Dihydroceramide desaturase 1 (Des1) catalyzes the last step of ceramide synthesis de novo, thus regulating the physiologically relevant balance between dihydrosphingolipids and sphingolipids. Here we report on the configurational preference of Des1 towards isomeric Δ6-unsaturated dihydroceramide analogs and the discovery of a potent Des1 inhibitor.

Graphical abstract: From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

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Publication details

The article was received on 13 Oct 2016, accepted on 27 Mar 2017 and first published on 27 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC08268H
Citation: Chem. Commun., 2017,53, 4394-4397
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    From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

    A. Pou, J. Abad, Y. F. Ordóñez, M. Garrido, J. Casas, G. Fabriàs and A. Delgado, Chem. Commun., 2017, 53, 4394
    DOI: 10.1039/C6CC08268H

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