Jump to main content
Jump to site search


Ultrafast Charge-Conversional Nanocarrier for Tumor-Acidity-Activated Targeted Drug Delivery

Abstract

Nanocarriers with tumor-acidity-activated charge-conversional ability are of particular interest for targeted drug delivery in the field of precision nanomedicine. Nevertheless, the key challenge of this strategy is the slowness of reversing the surface charge at the tumor tissue. As a proof-of-concept, we systhesized the amphiphilic triblock polymers poly(ethylene glycol)-block-poly(2-carboxyethyl acrylate)-block-poly(2-azepane ethyl methacrylate) (PEG-b-PCEA-b-PAEMA) to prepare the cisplatin-loaded nanocarriers UCC-NP/Pt. The PAEMA block at the physiological pH values was hydrophobic, which formed the core of UCC-NP/Pt. In contrast, at the tumor acidity, the tertiary amine groups of PAEMA block rapidly protonated, resulting in the ultrafast charge conversion of UCC-NP/Pt within 10 s. Such ultrafast charge-conversional effect more efficiently enhanced tumor cell internalization of nanocarrier, thus achieving targeted drug delivery, which in turn exhibited superior anticancer efficacy even in the cisplatin-resistant cells. This approach provides new avenues for tumor-acidity-activated targeted drug delivery.

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Nov 2017, accepted on 28 Nov 2017 and first published on 29 Nov 2017


Article type: Paper
DOI: 10.1039/C7BM01025G
Citation: Biomater. Sci., 2017, Accepted Manuscript
  •   Request permissions

    Ultrafast Charge-Conversional Nanocarrier for Tumor-Acidity-Activated Targeted Drug Delivery

    J. Wang, J. Liu, S. Iqbal, X. Du, Y. Yuan, X. Yang and H. Li, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM01025G

Search articles by author

Spotlight

Advertisements