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Therapeutic Applications of Iron Oxide Based Nanoparticles in Cancer: Basic Concepts and Recent Advances

Abstract

Nanotechnology has introduced new techniques and phototherapy approaches to fabricate and utilize nanoparticles for cancer therapy. These phototherapy approaches such as photothermal therapy (PTT) and photodynamic therapy (PDT) hold great promise to overcome the limitations of traditional treatment ways. In phototherapy, magnetic iron oxides nanoparticles (IONPs) are of paramount importance due to their wide range of biomedical applications. This review covers the basic concepts, different therapy approaches (PTT, PDT, magnetic hyperthermia therapy (MHT), chemotherapy and immunotherapy), intrinsic properties, mechanisms of cell death, and a brief overview about recent developments using IONPs with focusing on its therapeutic applications. Much attention is devoted to elaborating the different parameters, intracellular behavior and limitations of MHT. Bimodal therapies which act alone or in a combination with other modalities are also discussed. The review highlights some limitations in explored research areas and suggests future directions to overcome these limitations.

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Publication details

The article was received on 01 Nov 2017, accepted on 22 Dec 2017 and first published on 22 Dec 2017


Article type: Review Article
DOI: 10.1039/C7BM00999B
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Therapeutic Applications of Iron Oxide Based Nanoparticles in Cancer: Basic Concepts and Recent Advances

    M. Saeed, W. Ren and A. Wu, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00999B

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