Bone-targeting poly(ethylene sodium phosphate)

Yasuhiko Iwasaki; Atsushi Yokota; Akihisa Otaka; Naoyuki Inoue; Akane Yamaguchi; Toru Yoshitomi; Keitaro Yoshimoto; Masashi Neo

doi:10.1039/C7BM00930E

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Bone-targeting poly(ethylene sodium phosphate)†

Yasuhiko Iwasaki,

*^ab Atsushi Yokota,^c Akihisa Otaka,

^b Naoyuki Inoue,^a Akane Yamaguchi,^d Toru Yoshitomi,^d Keitaro Yoshimoto^de and Masashi Neo^c

Author affiliations

* Corresponding authors

^a Department of Chemistry and Materials Engineering, Kansai University, 3-3-35, Yamate-cho, Suita-shi, Osaka 564-8680, Japan
E-mail: yasu.bmt@kansai-u.ac.jp

^b ORDIST, Kansai University, 3-3-35, Yamate-cho, Suita-shi, Osaka 564-8680, Japan

^c Department of Orthopedic Surgery, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan

^d Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro, Tokyo 153-8902, Japan

^e JST, PRESTO, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan

Abstract

Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a promising polymer for bone-targeted therapies.

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Article information

DOI: https://doi.org/10.1039/C7BM00930E
Article type: Communication
Submitted: 12 Oct 2017
Accepted: 17 Nov 2017
First published: 21 Nov 2017

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Biomater. Sci., 2018,6, 91-95

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Bone-targeting poly(ethylene sodium phosphate)

Y. Iwasaki, A. Yokota, A. Otaka, N. Inoue, A. Yamaguchi, T. Yoshitomi, K. Yoshimoto and M. Neo, Biomater. Sci., 2018, 6, 91 DOI: 10.1039/C7BM00930E

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Biomaterials Science

Bone-targeting poly(ethylene sodium phosphate)†

Abstract

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Bone-targeting poly(ethylene sodium phosphate)

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