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Collagen-binding VEGF targeting cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction

Abstract

An effective therapy for chronic myocardial infarction (MI) has yet to be developed. Vascular endothelial growth factor (VEGF) promotes angiogenesis and improves cardiac function after MI. However, non-targeting delivery of VEGF decreases its therapeutic efficacy. In this study, targeting to the nature cardiac extracellular matrix, a collagen-binding domain (CBD) VEGF was used to bind specifically to the collagen-rich cardiac extracellular matrix. When intramyocardially injected into the peri-infarct region of the chronically infarcted porcine heart, CBD-VEGF attenuated the remodeling of the left ventricle with a decreased infarct size and promoted cardiomyocyte survival and angiogenesis 3 months after injection. In the 12-month trial, mature vessel networks and myocardium-like tissues were observed in the infarct region after CBD-VEGF injection. Also these beneficial effects might derived from that CBD-VEGF significantly protected cardiomyocytes from apoptosis and recruited cardiac progenitor cells to infarction region.These results demonstrated that CBD-VEGF could be a promising therapeutic strategy for chronic MI.

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Publication details

The article was received on 30 Sep 2017, accepted on 04 Dec 2017 and first published on 05 Dec 2017


Article type: Paper
DOI: 10.1039/C7BM00891K
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Collagen-binding VEGF targeting cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction

    C. Shi, Y. Zhao, Y. Yang, C. Chen, X. Hou, J. Shao, H. Yao, Q. Li, Y. Xia and J. Dai, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00891K

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