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Advanced smart-photosensitizers for more effective cancer treatment

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Abstract

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

Graphical abstract: Advanced smart-photosensitizers for more effective cancer treatment

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Publication details

The article was received on 26 Sep 2017, accepted on 01 Nov 2017 and first published on 01 Nov 2017


Article type: Minireview
DOI: 10.1039/C7BM00872D
Citation: Biomater. Sci., 2018, Advance Article
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    Advanced smart-photosensitizers for more effective cancer treatment

    W. Park, S. Cho, J. Han, H. Shin, K. Na, B. Lee and D. Kim, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C7BM00872D

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