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Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

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Abstract

Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine–glycine–aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.

Graphical abstract: Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

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Publication details

The article was received on 08 Sep 2017, accepted on 29 Sep 2017 and first published on 03 Oct 2017


Article type: Communication
DOI: 10.1039/C7BM00826K
Citation: Biomater. Sci., 2017, Advance Article
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    Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

    X. Xu, L. Zhao, X. Li, P. Wang, J. Zhao, X. Shi and M. Shen, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00826K

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