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Coordination-driven Assembly of Catechol-modified Chitosan for Kidney-specific Delivery of Salvianolic Acid B to Treat Renal Fibrosis

Abstract

Kidney-specific delivery is critically important for treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial-mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated kidney-specific biodistribution of the nanocomplex. The anti-fibrosis effect of HChi-Ca-Sal B was tested in a mouse model of unilateral ureteral obstruction (UUO). Significant attenuation of the morphological lesions and the levels of extracellular matrix (ECM) proteins in the tubulointerstitium were observed in mice treated with HChi-Ca-Sal B, suggesting that the nanocomplex was able to prevent fibrosis better than treatment with free Sal B. It was concluded that the HChi-Ca-Sal B nanocomplex showed specific renal targeting capacity and could be utilized to enhance Sal B delivery for treating renal fibrosis.

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Publication details

The article was received on 06 Sep 2017, accepted on 09 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7BM00811B
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Coordination-driven Assembly of Catechol-modified Chitosan for Kidney-specific Delivery of Salvianolic Acid B to Treat Renal Fibrosis

    J. Li, C. Zhang, W. He, H. Qiao, J. Chen, K. Wang, D. Oupicky and M. Sun, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00811B

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