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Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF

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Abstract

Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (half of the entire bladder was resected). The results demonstrated that the functional biomaterials could promote bladder smooth muscle, vascular, and nerve regeneration and improve the function of neobladders. Thus, the CBD-bFGF/BAM functional scaffold may be a promising biomaterial for bladder reconstruction.

Graphical abstract: Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF

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Publication details

The article was received on 02 Sep 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Paper
DOI: 10.1039/C7BM00806F
Citation: Biomater. Sci., 2017, Advance Article
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    Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF

    C. Shi, W. Chen, B. Chen, T. Shan, W. Jia, X. Hou, L. Li, G. Ye and J. Dai, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00806F

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