Jump to main content
Jump to site search


Bladder regeneration in a canine model using bladder acellular matrix loaded with collagen-binding bFGF

Abstract

Bladder reconstruction remains challgenging for urological suregery due to lack of suitable regenerative scaffolds. In our previous study, a collagen-binding basic fibroblast growth factor (CBD-bFGF) to enhance the binding of bFGF to collagen scaffolds, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate bladder acellular matrix (BAM) scaffold and the CBD-bFGF/BAM functional scaffold was assessed in the canine model with a large segment defect (half part of the entire bladder resection). The results demonstrated that the functional biomaterials could promote bladder smooth muscle, vascular and nerve regeneration, and improve function of neo-bladders. Thus, the CBD-bFGF/BAM functional scaffold might be a promising biomaterial for bladder reconstruction.

Back to tab navigation

Publication details

The article was received on 02 Sep 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Paper
DOI: 10.1039/C7BM00806F
Citation: Biomater. Sci., 2017, Accepted Manuscript
  •   Request permissions

    Bladder regeneration in a canine model using bladder acellular matrix loaded with collagen-binding bFGF

    J. Dai, C. Shi, W. Chen, B. Chen, T. Shan, W. Jia, X. Hou, L. Li and G. Ye, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00806F

Search articles by author

Spotlight

Advertisements