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Multifunctional UCNPs@MnSiO3@g-C3N4 nanoplatform: improved ROS generation and reduced glutathione levels for high efficient photodynamic therapy

Abstract

Photodynamic therapy (PDT) as a novel technique has been extensively employed in cancer treatment by utilizing reactive oxygen species to kill malignant cells. However, the poor performance of photosensitizer itself, limited penetration depth and the overexpression of glutathione (GSH) in cancer cells are the major obstacles facing the actual clinical application of PDT. Inspired by the challenges mentioned above, here we put forward a multifunctional nanoparticles via utilizing mesoporous manganese silicate (MnSiO3) coated upconversion nanoparticles (UCNPs) as nanocarrier for loading highly fluorescent graphitic-phase carbon nitride quantum dots (g-C3N4 QDs) to simultaneously act as photosensitive drug and imaging agent. The surface modification of nanoparticles with polyethylene glycol (PEG) endows the samples with excellent biocompatibility and long-term in vivo circulation (denoted as UMCNs-PEG). Taking advantages of the inherent performance of as-synthesized nanoparticles, multimodality imaging including upconversion luminescence (UCL), computed tomography (CT) and magnetic resonance imaging (MRI) have been achieved, which is conducive to provide effective treatment information by real-time monitoring properties. In vivo photodynamic therapy to achieve effective tumor inhibition is then realized, without inducing significant toxicity to the treated mice. As a result, this work provides a novel paradigm with highly integrated functionalities, which exhibits excellent prospects not only for imaging-guided photodynamic anticancer therapeutic but also encourages us to further explore new type of multifunctional nanoparticles for biomedical applications.

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Publication details

The article was received on 01 Sep 2017, accepted on 06 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7BM00798A
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Multifunctional UCNPs@MnSiO3@g-C3N4 nanoplatform: improved ROS generation and reduced glutathione levels for high efficient photodynamic therapy

    L. Feng, F. He, Y. Dai, S. Gai, C. Zhong, C. Li and P. Yang, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00798A

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