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Sequential growth of CaF2:Yb,Er@CaF2:Gd nanoparticles for efficient magnetic resonance angiography and tumor diagnosis

Abstract

It is a significant challenge to develop nanoscale magnetic resonance imaging (MRI) contrast agents with high performance of relaxation. In this work, the Gd3+-doped CaF2-based core-shell nanoparticles of CaF2:Yb,Er@CaF2:Gd with sub-10 nm size were controllable synthesized by a facile sequential growth method. The as-prepared hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles modified using PEG-PAA di-block copolymer benefited by the existence of Gd only in the outer CaF2 layer of the nanoparticles, which exhibited a so high r1 of 21.86 mM-1s-1 under 3.0 T, seven times as high as that of commercial used gadopentetate dimeglumine (Gd-DTPA). Low cytotoxicity, no hemolysis phenomenon and no potential gadolinium ion leakage phenomenon of hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles have been observed and confirmed. Clear vascular details can be observed in the magnetic resonance angiography and obvious MR signal of 4T1 tumor area could be significantly improved by intravenous injection of hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles at a low dosage on mice. A series of in vivo biological safety evaluations confirmed the good biocompatibility of hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles, which might be employed in clinical blood pool imaging and tumor diagnosis as a safe and efficient MRI probe.

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Publication details

The article was received on 01 Sep 2017, accepted on 29 Sep 2017 and first published on 11 Oct 2017


Article type: Paper
DOI: 10.1039/C7BM00797C
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Sequential growth of CaF2:Yb,Er@CaF2:Gd nanoparticles for efficient magnetic resonance angiography and tumor diagnosis

    K. Liu, X. Yan, Y. Xu, L. Dong, L. Hao, Y. Song, F. Li, Y. Su, Y. Wu, H. Qian, W. Tao, X. Yang, W. Zhou and Y. Lu, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00797C

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