Jump to main content
Jump to site search


The biodistribution, excretion and potential toxicology of different-sized Pd nanosheets in mice following oral and intraperitoneal administration

Abstract

Two-dimensional (2D) Pd-based nanomaterials with strong near-infrared absorption have recently shown great application prospects in cancer diagnosis and therapy. Most previous studies mainly focused on understanding the in vivo behaviors and treatment effects of these Pd-based nanomaterials after intravenous injection into mice. However, it keeps unclear if other administration routes will affect the in vivo biodistribution, excretion and potential toxicity of Pd-based nanomaterials. In this study, for this first time we systematically explored the in vivo behaviors of different-sized Pd nanosheets (NSs) (approximate 5 nm, 30 nm and 80 nm) following oral feeding and intraperitoneal injection. It was found that Pd NSs with oral administration had a rather low accumulation that decreased with time in all examined organs, and became almost undetectable in these organs at 24 h post injection. In comparison, the intraperitoneal injected Pd NSs exhibited obvious time-dependent and size-dependent accumulations in the reticuloendothelial (RES) system including liver and spleen within 24 h post injection, and then the accumulation amounts decreased with the lapse of time. Moreover in tumor tissue, smaller-sized Pd NSs (5 nm) had higher uptake than that of larger-sized Pd NSs (30 nm and 80 nm). Excretion studies uncovered that more than 70%ID of Pd NSs could be rapidly excreted from the body through urine and feces within two days after oral administration, whereas Pd NSs with intraperitoneal injection could be gradually cleared, mainly via urine within 8 days. Further histological examination of organ sections and blood biochemistry analysis evidenced that these different-sized Pd NSs do not cause obvious toxicity to the treated mice at the tested period with the given dose. These results not only indicate that the biodistribution and excretion capabilities of Pd NSs are closely related to their administration routes, but also imply that the intraperitoneal injected Pd NSs have greater potentials for in vivo biomedical studies compared to oral feeding, because of their relatively higher tissue absorption and gradual excretion from the body. This study will provide valuable information for the clinical translation of 2D Pd-based nanomaterials.

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Aug 2017, accepted on 09 Oct 2017 and first published on 09 Oct 2017


Article type: Paper
DOI: 10.1039/C7BM00769H
Citation: Biomater. Sci., 2017, Accepted Manuscript
  •   Request permissions

    The biodistribution, excretion and potential toxicology of different-sized Pd nanosheets in mice following oral and intraperitoneal administration

    X. Chen, J. Li, Y. Huang, J. Wei, D. Sun and N. Zheng, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00769H

Search articles by author

Spotlight

Advertisements