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Cu2+-Complex of hydrophilic nitrogen-rich polymer dots applied as a new MRI contrast agent

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Abstract

We report on a novel Cu2+-complex of nitrogen-rich polymer dots for magnetic resonance imaging (MRI). The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 °C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. The obtained Cu2+-PVIm dot complexes display relaxivity (r1 = 1.05 mM−1 s−1) two times higher than Cu2+ in aqueous solution (r1 = 0.43 mM−1 s−1) and three times higher than Cu2+ in aqueous solution coordinated with VIm monomers (r1 = 0.32 mM−1 s−1), which show a remarkable contrast enhancement for T1-weighted MRI while efficiently labeling MCF-7 cells and other biomedical applications.

Graphical abstract: Cu2+-Complex of hydrophilic nitrogen-rich polymer dots applied as a new MRI contrast agent

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Publication details

The article was received on 11 Aug 2017, accepted on 27 Sep 2017 and first published on 27 Sep 2017


Article type: Paper
DOI: 10.1039/C7BM00731K
Citation: Biomater. Sci., 2017, Advance Article
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    Cu2+-Complex of hydrophilic nitrogen-rich polymer dots applied as a new MRI contrast agent

    M. Hu, J. Chen, J. Wang, Y. Zhang, L. Liu, P. C. Morais and H. Bi, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00731K

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