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A new developing class of gene delivery Messenger RNA-based therapeutics

Abstract

Gene therapy has long been held as having the potential to become a front line treatment of various genetic disorders. However, the direct delivery of nucleic acids to correct a genetic disorder has numerous limitations owing to the inability of naked nucleic acids (DNA and RNA) to traverse the cell membrane. Recently, messenger RNA (Mrna) based delivery has become a more attractive alternative to DNA due to the relatively easier transfection process, higher efficiency and safety profile. As with all gene therapy, the central challenge remains the efficient delivery of nucleic acids intracellularly. This review presents the recent progress in mRNA delivery, focusing on comparing the advantages and limitations of non-viral based delivery vectors.

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Publication details

The article was received on 06 Aug 2017, accepted on 29 Sep 2017 and first published on 02 Oct 2017


Article type: Review Article
DOI: 10.1039/C7BM00712D
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    A new developing class of gene delivery Messenger RNA-based therapeutics

    Z. Meng, J. O’Keeffe-Ahern, J. Lyu, L. Pierucci, D. Zhou and W. Wang, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00712D

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