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Degradable and Biocompatible Hydrogels Bearing Hindered Urea Bond


Hindered urea bond (HUB), recently reported as a new type of dynamic chemical bond, can be facilely constructed by mixing isocyanate and hindered amine. Here, we report the use of HUB in the design of degradable hydrogel materials for applications of stem cell encapsulation and delivery. Polyethyleneglycol (PEG) diamine was end-capped with HUB and allyl group with one-pot synthesis. The resulting polymer was cross-linked to form hydrogel under UV with the addition of 4-arm PEG thiol and photoinitiator. The degradation properties of the hydrogels were confirmed with NMR, GPC, weight loss, and protein release studies. We found that the degradation kinetics is dependent on the size of N-substituents, and the one with the tert-butyl group shows complete degradation within 2 days. The new hydrogel materials were also demonstrated to be biocompatible with hMSC, and the cell release kinetics can be facilely tuned over 5 days.

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Publication details

The article was received on 26 Jul 2017, accepted on 30 Sep 2017 and first published on 02 Oct 2017

Article type: Communication
DOI: 10.1039/C7BM00669A
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Degradable and Biocompatible Hydrogels Bearing Hindered Urea Bond

    H. YING, J. Yen, R. Wang, Y. Lai, J. Hsu, Y. Hu and J. Cheng, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00669A

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