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Development of drug-loaded polymer microcapsules for treatment of epilepsy

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Abstract

Despite significant progress in developing new drugs for seizure control, epilepsy still affects 1% of the global population and is drug-resistant in more than 30% of cases. To improve the therapeutic efficacy of epilepsy medication, a promising approach is to deliver anti-epilepsy drugs directly to affected brain areas using local drug delivery systems. The drug delivery systems must meet a number of criteria, including high drug loading efficiency, biodegradability, neuro-cytocompatibility and predictable drug release profiles. Here we report the development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mathematical modelling. Importantly, both forms of fabricated microcapsules are compatible with human brain derived neural stem cells and differentiated neurons and neuroglia, indicating clinical compliance for neural implantation and therapeutic drug delivery.

Graphical abstract: Development of drug-loaded polymer microcapsules for treatment of epilepsy

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Publication details

The article was received on 15 Jul 2017, accepted on 07 Sep 2017 and first published on 07 Sep 2017


Article type: Paper
DOI: 10.1039/C7BM00623C
Citation: Biomater. Sci., 2017, Advance Article
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    Development of drug-loaded polymer microcapsules for treatment of epilepsy

    Y. Chen, Q. Gu, Z. Yue, J. M. Crook, S. E. Moulton, M. J. Cook and G. G. Wallace, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00623C

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