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Facile synthesis of black phosphorus-Au nanocomoposites for enhanced photothermal cancer therapy and surface-enhanced Raman scattering analysis

Abstract

Black phosphorus (BP), a new type of two dimensional nanomaterials have attracted crucial attention in recent year owing to excellent properties and great potential in various chemical, physical, and biological fields. In this study, BP nanosheets loaded with Au nanoparticles (BP-Au NSs) is obtained by an one-step facile synthetic method. The Au nanostructures can not only enhance the photothermal efficiency of the nanocomposites, but also endow BP-Au NSs the potential as effective surface-enhanced Raman scattering (SERS) substrate for Raman biodetection. The cancer photothermal therapy (PTT) has been carried out in vitro and in vivo using BP-Au NSs as the nanoagents. Under the irradiation by 808 nm laser, BP-Au NSs are capable to produce sufficient hyperthermia to destroy the cancer cells, and the transplanted tumors in the most of tumor-bearing mice are disappeared, which is highly effective than the bare BP nanosheets. The PTT effect can also be monitored by the Raman technique, benefiting from the high SERS activity of BP-Au NSs. The molecular fingerprint features of breast tumor before and after PTT treatment are clearly identified using the SERS analysis. The theranostic applications of BP-Au NSs exhibit the promising potential in biomedicine.

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Publication details

The article was received on 05 May 2017, accepted on 23 Jun 2017 and first published on 29 Jun 2017


Article type: Paper
DOI: 10.1039/C7BM00414A
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Facile synthesis of black phosphorus-Au nanocomoposites for enhanced photothermal cancer therapy and surface-enhanced Raman scattering analysis

    G. Yang, Z. Liu, Y. Li, Y. Hou, X. Fei, C. Su, S. Wang, Z. Zhuang and Z. Guo, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00414A

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