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Issue 9, 2017
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Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers

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We report the synthesis and characterization of high-molecular weight poly(L-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride, high-molecular weight γ-benzyl protected poly(L-glutamic acid) brush polymers are synthesized. Controlled and complete deprotection of the benzyl groups using trimethylsilyl iodide resulted in poly(L-glutamic acid) based brush polymers with molecular weights up to 3.6 MDa, which may potentially be used to prepare size-controlled unimolecular polymeric nanomedicine for drug delivery applications. Camptothecin brush poly(L-glutamic acid) conjugates were prepared and their stability, drug release kinetics, and in vitro toxicity were studied.

Graphical abstract: Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers

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The article was received on 13 Apr 2017, accepted on 12 Jun 2017 and first published on 30 Jun 2017

Article type: Paper
DOI: 10.1039/C7BM00339K
Citation: Biomater. Sci., 2017,5, 1836-1844
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    Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers

    R. Baumgartner, D. Kuai and J. Cheng, Biomater. Sci., 2017, 5, 1836
    DOI: 10.1039/C7BM00339K

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