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Surface-modified polymers for cardiac tissue engineering

Abstract

Cardiovascular disease (CVD), leading to myocardial infarction and heart failure, is one of the major causes of death worldwide. The physiological system cannot significantly regenerate the capabilities of a damaged heart. Current treatment involves pharmacological and surgical interventions; however, less invasive and more cost-effective approaches are sought. Such new approaches are developed to induce tissue regeneration following injury. Hence, regenerative medicine has a key role in treating CVD. Recently, the extrinsic stimulation of cardiac regeneration has involved the use of potential polymers to stimulate stem cells toward differentiation of cardiomyocytes as a new therapeutic intervention in cardiac tissue engineering (CTE). The therapeutic potentiality of natural or synthetic polymers and cell surface interactive factors/polymer surface modifications for cardiac repair have been demonstrated in vitro and in vivo. This review will discuss recent advances in CTE using polymers and cell surface interactive factors that interact strongly with stem cells to trigger the molecular aspects of the differentiation or formulation of cardiomyocytes for the functional repair of heart injuries or cardiac defects.

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Publication details

The article was received on 06 Apr 2017, accepted on 03 Aug 2017 and first published on 03 Aug 2017


Article type: Review Article
DOI: 10.1039/C7BM00309A
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Surface-modified polymers for cardiac tissue engineering

    A. Moorthi, Y. Tyan and T. Chung, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00309A

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