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Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice

Abstract

There is an urgent need for more efficient treatment for chronic wounds in diabetic patients especially with high risk of leg amputations. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In the previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. The present study investigates the effect of a heparin-mimetic peptide amphiphile (PA) nanofiber gel on full-thickness excisional wounds in a db/db diabetic mouse model, with emphasis on the ability of the PA nanofiber network to regulate angiogenesis and the expression of pro-inflammatory cytokines. Here, we showed that heparin-mimetic PA gel can support tissue neovascularization, enhance the deposition of collagen and expression of alpha-smooth muscle actin (α-SMA), and eliminate the sustained presence of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the diabetic wound site. As the absence of neovascularization and overexpression of pro-inflammatory markers are a hallmark of diabetes and interferes with wound recovery by preventing the healing process, the heparin-mimetic PA treatment is a promising candidate for acceleration of diabetic wound healing by modulating angiogenesis and local immune response.

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Publication details

The article was received on 25 Mar 2017, accepted on 11 May 2017 and first published on 15 May 2017


Article type: Paper
DOI: 10.1039/C7BM00251C
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice

    B. Senturk, B. M. Demircan, A. D. Ozkan, S. Tohumeken, T. Delibasi, M. O. Guler and A. B. Tekinay, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00251C

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