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Issue 6, 2017
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Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site

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Abstract

Anticancer drugs are commonly used as inhibitors of vascular smooth muscle cell (VSMC) proliferation in clinical treatments. This study aims to investigate how elemene affects the proliferation of VSMCs, the restenosis, and the reendothelialization after implanting the elemene-coated stents. VSMCs derived from rat aorta were used to test the cell proliferation, cell cycle, migration, apoptosis, cytoskeletal protein F-actin, intracellular Ca2+, IncRNA chip and gene expression of PCNA, P53, and Cx43 when cultured with elemene. It was found that elemene can inhibit proliferation, induce apoptosis and block the connections between VSMCs in a dose-dependent manner. IncRNA chip analysis has revealed that there was a significant difference in the expression of 1417 genes and 34 signaling pathways. Elemene liposome membranes prepared by electrostatic spray could also inhibit the proliferation of VSMCs. In addition, after implanting the elemene-coated stent into a rabbit iliac artery for 12 weeks, the surface of elemene-coated stents was fully covered with a layer of neointima and a few platelets. However, a large number of platelets aggregated and attached on the uncoated stents (control samples). In conclusion, elemene could inhibit VSMC proliferation in vitro, which involved the regulation of various signal transduction pathways, and elemene-coated stents could promote endothelialization after stent implantation. Thus, elemene has great potential for the clinical treatment of restenosis and reendothelialization.

Graphical abstract: Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site

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Publication details

The article was received on 08 Mar 2017, accepted on 24 Apr 2017 and first published on 27 Apr 2017


Article type: Paper
DOI: 10.1039/C7BM00190H
Citation: Biomater. Sci., 2017,5, 1144-1155
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    Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site

    W. Sun, Y. Huang, T. Yin, J. Wang, R. Du, J. Qiu, Y. Zhang, Y. Wang, J. Chen and G. Wang, Biomater. Sci., 2017, 5, 1144
    DOI: 10.1039/C7BM00190H

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