Jump to main content
Jump to site search

Issue 4, 2017
Previous Article Next Article

PEGylation corannulene enhances response of stress through promoting neurogenesis

Author affiliations

Abstract

Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene. Then, in vivo experiments were performed to determine the effects of PEGylation CoNps on the neural system. We found that PEGylation CoNps treatment increased short resting bouts, decreased locomotion activities and enhanced the response to stress. Most of these behavioral changes suggest that PEGylation CoNps lead to a greater reflection to stress, which is associated with neurotransmitter expression and neurogenesis. In line with the hypothesis, we found that PEGylation CoNps administration enhanced TH, DCX and MAP-2 expression in the hippocampus. These results indicated that PEGylation CoNps enhanced the neurogenesis of mice. Furthermore, pathological analysis showed that PEGylation CoNps caused little inflammation. These findings suggest that PEGylation CoNps are a potential functionalized carbon nanomaterial for promoting neurogenesis.

Graphical abstract: PEGylation corannulene enhances response of stress through promoting neurogenesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2017, accepted on 01 Mar 2017 and first published on 15 Mar 2017


Article type: Paper
DOI: 10.1039/C7BM00068E
Citation: Biomater. Sci., 2017,5, 849-859
  •   Request permissions

    PEGylation corannulene enhances response of stress through promoting neurogenesis

    X. Li, D. Sun, X. Li, D. Zhu, Z. Jia, J. Jiao, K. Wang, D. Kong, X. Zhao, L. Xu, Q. Zhao, D. Chen and X. Feng, Biomater. Sci., 2017, 5, 849
    DOI: 10.1039/C7BM00068E

Search articles by author

Spotlight

Advertisements