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Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets

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Abstract

Using a novel magnetic field bioreactor, this work evaluated the chondrogenesis of scaffold-free human mesenchymal stem cell sheets in response to static and variable magnetic fields, as well as mechanical stimulation via 4.4 μm magnetic particles. Neither static nor variable magnetic fields generated by 1.44–1.45 T permanent magnets affected cartilage formation. Notably, magnetic field-induced mechanical stimulation by magnetic particles, which applied forces to the cells and ECM statically (4.39 pN) or cyclically (1.06–63.6 pN; 16.7 mHz), also did not affect cartilage formation.

Graphical abstract: Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets

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Publication details

The article was received on 22 Jan 2017, accepted on 11 May 2017 and first published on 24 May 2017


Article type: Communication
DOI: 10.1039/C7BM00061H
Citation: Biomater. Sci., 2017, Advance Article
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    Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets

    A. D. Dikina, B. P. Lai, M. Cao, M. Zborowski and E. Alsberg, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00061H

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