Jump to main content
Jump to site search

Issue 6, 2017
Previous Article Next Article

Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces

Author affiliations

Abstract

In this study we investigate the formation of protein-resistant polymer surfaces, such as aliphatic polyesters, through the deposition of self-assemblies of amphiphilic poly(L-lactide)-b-poly(ethylene oxide), PLLA-b-PEO, copolymers as stable nanoparticles with a kinetically frozen PLLA core on model PLLA surfaces. The length of the PEO chains in the corona was tuned to achieve polymer brushes capable of preventing protein adsorption on PLA-based biomaterials. The spectroscopic ellipsometry, IR and XPS analysis, contact angle goniometry, and AFM proved that the PEO chains adopted a brush structure and were preferably exposed on the surface. The low-fouling properties of the physisorbed PLLA-b-PEO layers approached the ones of reactive grafting methods, as shown by surface plasmon resonance spectroscopy. The anti-fouling properties of the prepared PEO brushes provided sufficient interface to prevent cell adhesion as proved in vitro. Thus, the developed surface coating with PLLA-b-PEO colloids can provide an anti-fouling background for the creation of nanopatterned biofunctionalized surfaces in biomedical applications.

Graphical abstract: Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Jan 2017, accepted on 24 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7BM00009J
Citation: Biomater. Sci., 2017,5, 1130-1143
  •   Request permissions

    Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces

    E. Mázl Chánová, O. Pop-Georgievski, M. M. Kumorek, O. Janoušková, L. Machová, D. Kubies and F. Rypáček, Biomater. Sci., 2017, 5, 1130
    DOI: 10.1039/C7BM00009J

Search articles by author

Spotlight

Advertisements