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Issue 5, 2017
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NIR-emitting and photo-thermal active nanogold as mitochondria-specific probes

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Abstract

We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells.

Graphical abstract: NIR-emitting and photo-thermal active nanogold as mitochondria-specific probes

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Publication details

The article was received on 28 Dec 2016, accepted on 28 Feb 2017 and first published on 10 Mar 2017


Article type: Communication
DOI: 10.1039/C6BM00951D
Citation: Biomater. Sci., 2017,5, 966-971
  • Open access: Creative Commons BY license
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    NIR-emitting and photo-thermal active nanogold as mitochondria-specific probes

    S. Chakrabortty, M. Sison, Y. Wu, A. Ladenburger, G. Pramanik, J. Biskupek, J. Extermann, U. Kaiser, T. Lasser and T. Weil, Biomater. Sci., 2017, 5, 966
    DOI: 10.1039/C6BM00951D

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