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Issue 4, 2017
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Mineral binding peptides with enhanced binding stability in serum

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Abstract

Although calcium phosphate (CaP) binding peptides are used to link orthobiologics to orthopedic biomaterials, their binding stability in physiological environment is still unknown. In this study, we investigate the binding capability of a series of CaP-binding peptides and their binding stability in serum solutions, which are selected to resemble physiological conditions. The findings in this study may be applicable for designing robust orthobiologic delivery systems.

Graphical abstract: Mineral binding peptides with enhanced binding stability in serum

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Publication details

The article was received on 19 Dec 2016, accepted on 22 Feb 2017, published on 06 Mar 2017 and first published online on 06 Mar 2017


Article type: Communication
DOI: 10.1039/C6BM00928J
Citation: Biomater. Sci., 2017,5, 663-668
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    Mineral binding peptides with enhanced binding stability in serum

    J. S. Lee, X. Yu, A. J. Wagoner Johnson and W. L. Murphy, Biomater. Sci., 2017, 5, 663
    DOI: 10.1039/C6BM00928J

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