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Issue 4, 2017
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Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapy

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Abstract

Novel “zwitterionic” gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)-b-poly(lipoic methacrylate) (pMPC-b-pLA)}. In vitro, they exhibited low dark cytotoxicity and a high therapeutic efficacy to cancer cells. Their blood circulation half-life in vivo (t1/2, ∼10 h) was 20-fold longer than that of CTAB-Au NRs (t1/2, <30 min). After intravenous administration, they accumulated in tumour sites via an enhanced permeability and retention (EPR) effect and enabled destruction of human xenograft tumours in mice after exposure of the tumour location to NIR laser irradiation at 808 nm. These studies showed that the “zwitterionic” Au NRs had low toxicity and high photothermal efficacy both in vitro and in vivo due to the suprahydrophilic, biocompatible zwitterionic polymer coating layer. They may have the potential to be a promising NIR PTT agent in the biomedical field.

Graphical abstract: Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapy

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Publication details

The article was received on 16 Dec 2016, accepted on 24 Jan 2017 and first published on 06 Feb 2017


Article type: Paper
DOI: 10.1039/C6BM00918B
Citation: Biomater. Sci., 2017,5, 686-697
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    Zwitterionic gold nanorods: low toxicity and high photothermal efficacy for cancer therapy

    H. Jiang, D. Chen, D. Guo, N. Wang, Y. Su, X. Jin, G. Tong and X. Zhu, Biomater. Sci., 2017, 5, 686
    DOI: 10.1039/C6BM00918B

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