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Issue 4, 2017
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Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

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Abstract

A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.

Graphical abstract: Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

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Publication details

The article was received on 15 Dec 2016, accepted on 09 Feb 2017 and first published on 01 Mar 2017


Article type: Communication
DOI: 10.1039/C6BM00915H
Citation: Biomater. Sci., 2017,5, 658-662
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    Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

    X. Wang, D. Miao, X. Liang, J. Liang, C. Zhang, J. Yang, D. Kong, C. Wang and H. Sun, Biomater. Sci., 2017, 5, 658
    DOI: 10.1039/C6BM00915H

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