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Issue 5, 2017
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Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects

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Abstract

Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. However, the application of phototherapy is often compromised by its low efficiency. Herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rPAA@SWCNTs) with a photosensitizer, indocyanine green (ICG), for phototherapy. The as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core. Moreover, the high buffer capacity of the polycations facilitated the endosomal escape of nanoparticles via a proton-sponge effect. When irradiated with an 808 nm NIR laser, ICG/rPAA@SWCNTs could precisely damage mitochondria with high efficiency and produce reactive oxygen species (ROS) and hyperthermia, which further induced the ROS burst from damaged mitochondria. The overproduced ROS accumulated in mitochondria ultimately resulted in mitochondrial damage and cell death. Therefore ICG/rPAA@SWCNTs may be able to achieve an amplifying phototherapeutic effect.

Graphical abstract: Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects

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Publication details

The article was received on 02 Dec 2016, accepted on 19 Mar 2017 and first published on 20 Mar 2017


Article type: Paper
DOI: 10.1039/C6BM00878J
Citation: Biomater. Sci., 2017,5, 1022-1031
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    Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects

    Y. Liu, H. Li, J. Xie, M. Zhou, H. Huang, H. Lu, Z. Chai, J. Chen and Y. Hu, Biomater. Sci., 2017, 5, 1022
    DOI: 10.1039/C6BM00878J

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