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Issue 4, 2017
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Microvalve-based bioprinting – process, bio-inks and applications

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Bioprinting is an emerging research field that has attracted tremendous attention for various applications; it offers a highly automated, advanced manufacturing platform for the fabrication of complex bioengineered constructs. Different bio-inks comprising multiple types of printable biomaterials and cells are utilized during the bioprinting process to improve the homology to native tissues and/or organs in a highly reproducible manner. This paper, presenting a first-time comprehensive yet succinct review of microvalve-based bioprinting, provides an in-depth analysis and comparison of different drop-on-demand bioprinting systems and highlights the important considerations for microvalve-based bioprinting systems. This review paper reports a detailed analysis of its printing process, bio-ink properties and cellular components on the printing outcomes. Lastly, this review highlights the significance of drop-on-demand bioprinting for various applications such as high-throughput screening, fundamental cell biology research, in situ bioprinting and fabrication of in vitro tissue constructs and also presents future directions to transform the microvalve-based bioprinting technology into imperative tools for tissue engineering and regenerative medicine.

Graphical abstract: Microvalve-based bioprinting – process, bio-inks and applications

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Publication details

The article was received on 27 Nov 2016, accepted on 22 Jan 2017 and first published on 15 Feb 2017

Article type: Review Article
DOI: 10.1039/C6BM00861E
Citation: Biomater. Sci., 2017,5, 632-647
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    Microvalve-based bioprinting – process, bio-inks and applications

    W. L. Ng, J. M. Lee, W. Y. Yeong and M. Win Naing, Biomater. Sci., 2017, 5, 632
    DOI: 10.1039/C6BM00861E

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