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Issue 3, 2017
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Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo

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Abstract

Near-infrared (NIR) photothermal therapy (PTT) is a new approach to ablate cancer without affecting normal tissues. A pivotal concern of PPT is to develop photo-responsive agents with high biocompatibility as well as effective photothermal conversion efficiency. Copper sulfide (CuS) nanoparticles prepared are characterized by their low synthesis cost, wide NIR absorption range, good biocompatibility and favorable NIR photothermal conversion efficiency. CuS nanoparticles were then coated with mesoporous silicon dioxide (SiO2) by the Stober method, and further loaded with anticancer drug doxorubicin (DOX). The nanocomposites obtained were named CuS@MSN-DOX. The infrared thermal imaging of CuS@MSN-DOX demonstrated its favorable photothermal efficacy. The potential of CuS@MSN-DOX utilized as a multifunctional platform for combined PPT and chemotherapy was exploited both at the cell level and in a mice model. The result demonstrated that CuS@MSN-DOX was endowed with the synergistic effect of chemo-photothermal therapy, which confirmed that it is a promising candidate for combined therapy of cancer.

Graphical abstract: Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo

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Publication details

The article was received on 08 Sep 2016, accepted on 14 Dec 2016 and first published on 12 Jan 2017


Article type: Paper
DOI: 10.1039/C6BM00626D
Citation: Biomater. Sci., 2017,5, 475-484
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    Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo

    S. Peng, Y. He, M. Er, Y. Sheng, Y. Gu and H. Chen, Biomater. Sci., 2017, 5, 475
    DOI: 10.1039/C6BM00626D

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