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CVD graphene incorporating polymerized L-cysteine as an electrochemical sensing platform for simultaneous determination of dopamine and ascorbic acid

Abstract

A graphene platform electrode (GPE) was prepared directly by transferring chemical vapor deposition (CVD) graphene films from Cu foils to polyethylene terephthalate substrates with the aid of polymethyl-methacrylate, a distinct advantage over previously developed methods. L-cysteine (L-Cys) was polymerized on a GPE by one-step electrodeposition technique to form a poly-L-Cys/GPE. As a negatively charged polymer, the poly-L-Cys could adsorb positively charged dopamine (DA) and repel negatively charged ascorbic acid (AA) under optimum conditions. As a result, a novel electrochemical sensor for the simultaneous determination of DA and AA was developed. The electrochemical behaviors of DA and AA were investigated by cyclic voltammetry. Differential pulse voltammetry was used for determining DA and AA in their mixture, where the separation of oxidation peak potentials beteween DA and AA was about 175 mV. The broad linear response to DA and AA was presented by chronoamperometry with detection limits (S/N = 3) of 0.0531 μM and 0.2031 μM, respectively. In addition, the as-obtained sensor delivered good stability as well as high resistance to interference, and was successfully utilized in determining real samples. Consequently, the poly-L-Cys/GPE could be considered as a new promising DA and AA sensor, strongly indicating that the CVD graphene could be used successfully as a material in electrochemistry.

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Publication details

The article was received on 23 Oct 2017, accepted on 07 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7AY02489D
Citation: Anal. Methods, 2017, Accepted Manuscript
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    CVD graphene incorporating polymerized L-cysteine as an electrochemical sensing platform for simultaneous determination of dopamine and ascorbic acid

    D. He, S. Li, P. Zhang and H. Luo, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY02489D

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